Ingredients - Clinical Trial Citations

Rhodiola 
  • Darbinyan, V & Aslanyan, Gayane & Amroyan, E & Gabrielyan, E & Malmström, C & Panossian, Alexander. (2007). Clinical trial of Rhodiola in the treatment of mild to moderate depression. Nordic journal of psychiatry. 61. 343-8. 10.1080/08039480701643290. 

    Ashwagandha

    • Pratte, M. A., Nanavati, K. B., Young, V., & Morley, C. P. (2014). An Alternative Treatment for Anxiety: A Systematic Review of Human Trial Results Reported for the Ayurvedic Herb Ashwagandha (Withania somnifera). Journal of Alternative and Complementary Medicine20(12), 901–908. http://doi.org/10.1089/acm.2014.0177

     Chamomile

    • Srivastava, J. K., Shankar, E., & Gupta, S. (2010). Chamomile: A herbal medicine of the past with bright future. Molecular Medicine Reports3(6), 895–901. http://doi.org/10.3892/mmr.2010.377

      Lemon Balm

      • Scholey, A., Gibbs, A., Neale, C., Perry, N., Ossoukhova, A., Bilog, V., … Buchwald-Werner, S. (2014). Anti-Stress Effects of Lemon Balm-Containing Foods. Nutrients6(11), 4805–4821. http://doi.org/10.3390/nu6114805 
      Skullcap
      • Brock C, Whitehouse J, Tewfik I, Towell T. American Skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res. 2014 May28 (5):692-8. doi: 10.1002/ptr.5044. Epub 2013 Jul 22. PubMed PMID: 23878109.
        Bacopa (Brahmi)
        • Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, Limpeanchob N, Norman Scholfield C. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol. 2014;151(1):528-35. doi: 10.1016/j.jep.2013.11.008. Epub 2013 Nov 16. Review. PubMed PMID: 24252493.

        Magnolia

        • Talbott, S. M., Talbott, J. A., & Pugh, M. (2013). Effect of Magnolia on cortisol and psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition10, 37. http://doi.org/10.1186/1550-2783-10-37

        Passionflower

        • Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. 2001 Oct;26(5):363-7. PubMed PMID: 11679026.

        Valerian

        • Wheatley D. Kava and valerian in the treatment of stress-induced insomnia. Phytother Res. 2001 Sep;15(6):549-51. PubMed PMID: 11536390.

        L-Theanine

        • Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8. PubMed PMID: 18296328.

        Mucuna Pruriends 14% HPLC

        • Shukla, K. K., Mahdi, A. A., Ahmad, M. K., Jaiswar, S. P., Shankwar, S. N., & Tiwari, S. C. (2010). Mucuna pruriens Reduces Stress and Improves the Quality of Semen in Infertile Men. Evidence-Based Complementary and Alternative Medicine : eCAM7(1), 137–144. http://doi.org/10.1093/ecam/nem171
        St. John's wort
        • Apaydin, E. A., Maher, A. R., Shanman, R., Booth, M. S., Miles, J. N. V., Sorbero, M. E., & Hempel, S. (2016). A systematic review of St. John’s wort formajor depressive disorder. Systematic Reviews5(1), 148. http://doi.org/10.1186/s13643-016-0325-2

        Hops

        • Liu, L., Liu, C., Wang, Y., Wang, P., Li, Y., & Li, B. (2015). Herbal Medicine for Anxiety, Depression and Insomnia. Current Neuropharmacology13(4), 481–493. http://doi.org/10.2174/1570159X1304150831122734
        Plant Oils
        • Lin, T.-K., Zhong, L., & Santiago, J. L. (2018). Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. International Journal of Molecular Sciences19(1), 70. http://doi.org/10.3390/ijms1901007

        Phytoceramides

        • Guillou S, Ghabri S, Jannot C, Gaillard E, Lamour I, Boisnic S. The moisturizing effect of a wheat extract food supplement on women's skin: a randomized, double-blind placebo-controlled trial. Int J Cosmet Sci. 2011 Apr;33(2):138-43. doi: 10.1111/j.1468-2494.2010.00600.x. PubMed PMID: 20646083.

        Psyllium Powder

        • McRorie, J. W. (2015). Evidence-Based Approach to Fiber Supplements and Clinically Meaningful Health Benefits, Part 2: What to Look for and How to Recommend an Effective Fiber Therapy. Nutrition Today50(2), 90–97. http://doi.org/10.1097/NT.0000000000000089

        Melatonin

        • Sánchez-Barceló EJ, Mediavilla MD, Tan DX, Reiter RJ. Clinical uses of melatonin: evaluation of human trials. Curr Med Chem. 2010;17(19):2070-95. Review. PubMed PMID: 20423309.
        Valerian
        • Bent, S., Padula, A., Moore, D., Patterson, M., & Mehling, W. (2006). Valerian for Sleep: A Systematic Review and Meta-Analysis. The American Journal of Medicine119(12), 1005–1012. http://doi.org/10.1016/j.amjmed.2006.02.026

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